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Preventive medications in pediatric migraine: a network meta-analysis

Kaplan-Meier analysis revealed that lower GPX4 expression, as determined by the cutoff value with the lowest FDR/highest significance for each ICI target, predicted better survival in women treated with either anti-CTLA4 (Supplementary 3A) or anti-PD1 (Supplementary 3B), yet worse survival in women treated with anti-PDL1 (Supplementary 3C)

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Under hypoxic conditions, HIF-1 promotes PD-L1 upregulation, reinforcing immune evasion through both metabolic and immunoregulatory mechanisms [84]